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Answer to your Health Question

Question (09/27/2012):

Title: Lymph nodules in liver, lung, digestive system, kidney, bladder, spleen and pancreas.

I had an 11 mm lymph nodule on my liver for about 1year.

And a 7.0 mm pulmonary lymph nodule in my middle right lung lobe from 2010 until it disappeared in 2012.

I have multiple lymph nodules in my digestive system as well as very large golf ball size inflammatory mass in my upper right quadrant.

I had a 3.6 lymph nodule above and partially on my right kidney as well as several in and on my bladder, spleen and pancreas.

They were there anywhere from 8 months to 2 years before they were suddenly gone.

I have swelling of lymph gland on each side of my jaw bone behind my ears underneath my chin and both sides and back of my neck several times a month that usually disappear in about 4 days and later return.

Do these symptoms bring to mind any disease or condition that you know of?

It has been this way for the last 5 to 6 years.

Please help give me a place to start.


Answer:

Thank you very much for your question.

A lymph nodule is a small, localized collection of lymphoid tissue, usually located in the loose connective tissue beneath wet epithelial (covering or lining) membranes, as in the digestive system, respiratory system, and urinary bladder.

Lymph nodules form in regions of frequent exposure to microorganisms or foreign materials and contribute to the defense against them.

The nodule differs from a lymph node in that it is much smaller and does not have a well-defined connective-tissue capsule as a boundary.

It also does not function as a filter, because it is not located along a lymphatic vessel.

Lymph nodules frequently contain germinal centers-sites for localized production of lymphocytes.

In the small intestine, collections of lymph nodules are called Peyer's patches.

The tonsils are also local regions where the nodules have merged together.

Certain diseases affect lymph nodes with characteristic consistency and location.

Lymphadenopathy is a term meaning "disease of the lymph nodes."

It is, however, almost synonymously used with "swollen/enlarged lymph nodes."

In this case, the lymph nodes are palpable, and are a sign of various infections and diseases.

Rapid growth of pulmonary perifissural nodules is not a predictor of malignancy.

Incidentally found solitary pulmonary nodules (SPN) are increasing due to liberal use of high resolution CT scans.

Incidental visualization of indeterminate pulmonary nodules is considered a clinical dilemma.

Lymphatic nodules are sites of lymphocyte (B-cells) proliferation/activation.

The basic structure of a lymphatic nodule is described as a germinal center, where B-lymphocytes have activated and increased in size, surrounded by small, inactivated and proliferating B-cells.

These lymphatic nodules cab form anywhere in the body when B-cells are activated by their specific antigen.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease which is characterized by abnormal B lymphocytes (often simply called B cells) activation.

Systemic lupus erythematosus (SLE) symptoms vary from person to person, and may come and go.

Swollen lymph nodes are a common symptom of SLE.

Common areas where the swollen lymph nodes can be felt (with the fingers) include:

-Under the jaw and chin

-Behind the ears

-On the back of the head

-Neck (there is a chain of lymph nodes on either side of the front of the neck, both sides of the neck, and down each side of the back of the neck).


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