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platelet count | ITP | Papaya leaf juice
published on September 6 , 2012 in The Journal of Thrombosis and
Thrombolysis aimed to evaluate the efficacy, cost, and effects of
anti-D immunoglobulin (anti-D Ig), methylprednisolone, or intravenous
immunoglobulin (IVIG) therapy on the development of chronic disease
in children who are Rh-positive with diagnosed immune thrombocytopenic
with newly diagnosed ITP and platelet count <20,000/mm(3) were
prospectively randomized to treatment with anti-D Ig (50 ?g/kg), methylprednisolone
(2 mg/kg/day), or IVIG (0.4 g/kg/day, 5 days).
children with a mean age of 6.7 years were divided into three equal
groups. No difference was observed between platelet counts before
treatment and on day 3 of treatment.
platelet counts at day 7 were lower in the methylprednisolone group
than in the IVIG group (P = 0.03).
anti-D Ig group, hemoglobin and hematocrit levels were significantly
lower at the end of treatment (P < 0.05).
ITP developed in 30 % of the anti-D Ig group, 35 % of the methylprednisolone
group, and 25 % of the IVIG group, but no significant difference was
noted among the groups.
analysis revealed that the mean cost of IVIG was 7.4 times higher
than anti-D Ig and 10.9 times higher than methylprednisolone.
treatment of ITP in childhood, one 50 ?g/kg dose of anti-D Ig has
similar effects to IVIG and methylprednisolone.
patients who were treated with anti-D Ig, serious anemia was not observed,
and the cost of treatment was less than that of IVIG treatment.
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