to your Health Question
Is it safe to
take birth control pills when I suffer from Chronic Granulomatous Disease?
Dear Juanita ,
There is not scientific evidence to answer your question . We wouldn't
recommend to take birth control pills for your safe but would recommend
in order to avoid that the disease becomes to inherit.
In our humble opinion you should not take birth control pills based on
the following facts:
Chronic granulomatous disease (CGD),an inherited disorder of phagocytic
cells, results from an inability of phagocytes to produce bactericidal
super oxide anions (O2-).
A phagocyte is a cell that ingests and destroys foreign matter such as
microorganisms or debris via a process known as phagocytosis
As you well know CGD is a syndrome of recurrent infections. Birth control
pills are a synthetic form of the hormones progesterone and estrogen.
Estrogen is an important hormone found in both men and women. Progesterone
is a female hormone that stimulate and regulate various functions.
EE2, 17a-ethinyloestradiol (or 17-alfa-ethinyloestradiol) ,is the most
potent estrogen and an active ingredient in birth control pills.
Upon EE2 treatment, estrogen receptor alpha (ER-alpha) represses the expression
of hepatic transporters and may contribute to development of the EE2-induced
Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion
and bacterial killing. TNF- alpha (or Tumor necrosis factor) is a polypeptide
cytokine produced primarily by mononuclear phagocytes