Answer to your Health Question

Question: Is it safe to take birth control pills when I suffer from Chronic Granulomatous Disease?



Dear Juanita ,

There is not scientific evidence to answer your question . We wouldn't recommend to take birth control pills for your safe but would recommend in order to avoid that the disease becomes to inherit.

In our humble opinion you should not take birth control pills based on the following facts:

Chronic granulomatous disease (CGD),an inherited disorder of phagocytic cells, results from an inability of phagocytes to produce bactericidal super oxide anions (O2-).

A phagocyte is a cell that ingests and destroys foreign matter such as microorganisms or debris via a process known as phagocytosis

As you well know CGD is a syndrome of recurrent infections. Birth control pills are a synthetic form of the hormones progesterone and estrogen.

Estrogen is an important hormone found in both men and women. Progesterone is a female hormone that stimulate and regulate various functions.

EE2, 17a-ethinyloestradiol (or 17-alfa-ethinyloestradiol) ,is the most potent estrogen and an active ingredient in birth control pills.
Upon EE2 treatment, estrogen receptor alpha (ER-alpha) represses the expression of hepatic transporters and may contribute to development of the EE2-induced hepatotoxicity.

Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing. TNF- alpha (or Tumor necrosis factor) is a polypeptide cytokine produced primarily by mononuclear phagocytes