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Answer to your Health Question

Question (10/02/2012):

Title: What are signs and or symptoms of inflammatory masses?

In February I had abdominal surgery.

The 2 deep layers were sewn up with vicryl and the outside incision with staples.

It never healed.

In June another surgery was done to drain multiple draining fistulas.

Then each stitch of the vicryl and replaced with monofilament sutures.

A large inflammatory mass was removed along with tissue abdominal muscle and skin.

It was flushed multiple times with antibiotic solution and the surface incision was closed with staples.

It is now October and the incision will close then later 2 holes will open up drain then close again.

It is painful all around the incision and there are some very hard knots scattered around the incision that are palpable.

And just touching it feels like rubbing crushed glass in wound to touch it.

What are signs and or symptoms of inflammatory masses?

Answer:

Thank you very much for your question.

The most frequently reported symptoms of inflammatory mass are decreased therapeutic response, pain, and neurological deficit/dysfunction.

Serious reported symptoms include paralysis and other neurological impairments.

The phenomenon of inflammatory masses at the tips of intrathecal drug administration catheters was the subject of a recent case-compilation report and a number of animal studies.

The evidence suggests that the long-term administration of opioids, especially morphine, caused the inflammatory masses that were observed in humans and in two species of animals.

A relationship probably exists between mass formation and intrathecal morphine doses or concentration.

The most plausible hypothesis with regard to the cause of intrathecal catheter tip mass lesions implicates the administration of relatively high-concentration or high-dose opiate drugs or the use of drugs and admixtures that are not labeled for intrathecal use.

Patients who require high-dose intraspinal opioid therapy and those who receive drugs or admixtures that are not approved for intrathecal use should be monitored closely for signs of an extra-axial mass or catheter malfunction.

Prompt diagnosis and treatment may preserve neurological function.

Inflammatory masses have been reported in patients who receive intrathecal therapy through the SynchroMed® and IsoMed® infusion systems.

Inflammatory mass is a chronic inflammatory or granulomatous mass at or near the tip of intrathecal catheters and has been reported with the infusion of morphine, baclofen and other physician-prescribed drugs and/or mixtures, including pharmacy-compounded drugs.


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