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Answer to your Health Question

Question:

Hello,

I was recently sent a letter by the hospital I attend annually for my hypopituitarism condition.

This is the diagnosis I was given:

HYPOPITUITARISM DIAGNOSED IN THE FIRST YEAR OF LIFE GROWTH HORMONE ACTH AND GONADOTROPHIC INSUFFICIENCY MRI 2009 - ESSENTIALLY EMPTY PITUITARY FOSSA WITH ECTOPIC POSTERIOR PITUITARY.

Could you please explain to me what this means and what effect it may have on my fertility?

Thanks.

Answer:

Fertility outcomes in hypopituitaric women are about half of those reported in isolated hypogonadotropic hypogonadism; GH deficiency (GHD) is a major contributor to poor pregnancy rate.

In females, GH has a role not only as a modulator on gonadotropins, mediated by the property of IGF-I to amplify the action of both LH and FSH on granulosa, but also, through a direct GH action, on follicular maturation.

GH treatment seems to play an important role in the sensibilization of ovary responsivity and uterine morpholgy in GHD patients.

Growth hormone (GH) is a protein-based peptide hormone. It stimulates growth, cell reproduction and regeneration in humans and other animals.

ACTH o Adrenocorticotropic hormone is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland.

Gonadotrophic hormone is a hormone secreted by the anterior pituitary gland and placenta; stimulates the gonads and controls reproductive activity.

The pituitary fossa is a depression of the sphenoid bone housing the pituitary gland.

Ectopic posterior pituitary or neurohypophysis is an unusual congenital anomaly of the pituitary and is often associated with hypoplastic or absent pituitary gland.

Hormone problems cause around a quarter of all infertility cases and the pituitary gland is very important in this connection.


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