What percentage of patients with allergic alveolitis also have sarcoidosis
and why? .
been diagnosed with Sarcoidosis by my neurologist and Allergic Aveolitis
better known as (farmers lung) by my pulmonologist.
who handles my hypothyroidism and immune deficiency says that in a
lot of cases where the patient is immune deficient that the 2 diagnosis
go hand in hand.
true? And what % of patients with allergic alveolitis also have sarcoidosis
you very much for your question.
is sure what causes sarcoidosis.
is a systemic autoimmune process.
allergic alveolitis is caused by hypersensitivity to inhaled organic
allergic alveolitis and pulmonary sarcoidosis are granulomatous diseases
of the lung for which clinical presentation and anatomic site of granuloma
Extrinsic allergic alveolitis is caused by inhaled antigens, whereas
the nature and sourceof the inciting antigen in sarcoidosis is unknown.
of a scientific work from König G, Baur X, and Fruhmann G. indicated
that of 46 patients with sarcoidosis, there was an exposure to type
III allergens in 14 subjects.
examination of 2 patients diagnosed as having sarcoidosis there were
distinct features suggesting farmer's lung too.
challenge recording airway resistance, CO transfer factor and other
clinical features confirmed farmer's lung disease in these patients.
there are sometimes poor clinical and uncertain histological differences,
inhalative challenge is considered an important diagnostic procedure
to differentiate hypersensitivity pneumonitis from sarcoidosis.
is generally characterized by a CD4+ lymphocyte predominance in bronchoalveolar
lavage fluid (BALF), whereas in extrinsic allergic alveolitis (EAA)
a CD8+ lymphocyte predominance is found.
allergic alveolitis and sarcoidosis are two granulomatosis of the
lung characterized by non- -necrotizing granuloma. Both have typical
bronchoalveolar lavage immunology, with opposite CD4/CD8 relation.
sarcoidosis does not have such well defined etiology as extrinsic
thought that sarcoidosis of the lungs begins with alveolitis.
can cause alveolitis.
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