Question:
Hi My
Brother has very low platelet counts since 10 days he was detected
with TB and was given Rifampicin due to which his platelet count got
low until 8500 and now since 3 days it is 15000 stagnant and his SGPT
was high too i.e 1870 now its 110...
Kindly
suggest some remedies which can increase his platelet counts.
Shipra
Answer:
Dear
Shipra,
Severe
thrombocytopenia may occur during administration and readministration
of rifampicin.
Generally,
the most common offending agent for the causation of thrombocytopenia
secondary to antituberculous drugs is rifampicin. A literature search
revealed a total of about 35 cases of rifampicin-induced thrombocytopenia.
Rifampicin
can occasionally cause thrombocytopenia and purpura with or without
other symptoms of abnormal bleeding when used intermittently.
The occurrence
of isolated thrombocytopenia in a patient taking several medications
presents a challenging clinical problem.
A provisional
diagnosis of rifampicin-induced thrombocytopenia should be made.
If the
platelet count is below 20,000, people are usually treated in a hospital
or advised to stay in bed to avoid injury. They are usually given
a transfusion of platelets. If the platelet count is 20,000 to 30,000
and excessive bleeding occurs, platelets are usually transfused.
Treating
a disorder that has reduced the platelet count often restores the
count to normal. If taking rifampicin is the cause, it is usually
discontinued.
Thrombocytopenia
is an uncommon but potentially life-threatening complication of certain
antitubercular drugs and is characterized by rapid destruction of
platelets whenever the offending drug is taken by the susceptible
person.
The diagnosis
of drug-induced thrombocytopenia can be supported only by resolution
of thrombocytopenia after discontinuation of therapy with the suspected
drug.
Platelet
count should be monitored regularly and platelets should be transfused
to maintain levels above 20000/mm 3. Corticosteroids are of no benefit
in drug-induced thrombocytopenia.
Plasmapheresis
can be helpful in some cases. Offending drug should not be reused
as only a minute quantity of drug is needed to trigger this adverse
drug reaction.
You can
find more information related to your question at:
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kinds of food can increase platelets?
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