ITP and alcohol
like to know how severely alcohol affects a person with ITP.
have moderate alcohol, and yet behave as though I had been drinking
be questioned and people would think I was being dishonest about the
quantity of alcohol I had consumed. I became very disillusioned and
depressed, as I always enjoyed a couple of glasses of wine, but it
was thought that through my behavior, I had had much more.
like to get clarity on what alcohol does to you if you have ITP.
you very much for your question.
to Cowan DH , ample data exist indicating that alcoholism profoundly
affects the hemostatic mechanism.
patients without cirrhosis, the primary effect is on the blood platelet.
Both quantitative and qualitative abnormalities appear during ethanol
thrombocytopenia appears to be due to a combination of events: an
increased rate of platelet destruction leading to decreased platelet
survival and ineffective thrombopoiesis resulting in decreased effective
abnormalities are also multiple and include decreased platelet aggregation,
release, and procoagulant activity and decreased storage pool nucleotides,
cyclic AMP, and MAO activity.
and metabolic abnormalities are associated with striking disturbances
in ultrastructural morphology.
defects cause prolongation of the bleeding time and place affected
patients at risk for hemorrhagic complications.
between the quantitative abnormalities and the occurrence of thrombocytopenia
is obscure, although their severity appears to increase in parallel.
defects are readily corrected after cessation of drinking. Hence,
their long-term significance, absent development of cirrhosis, is
patients with cirrhosis, both platelet abnormalities and coagulation
defects may be present. Which predominates in severity varies with
the chronicity of the underlying clinical state, the duration of the
defects is more likely to be prolonged if not permanent.
owing to the mechanism of their development, treatment or correction
of the defects is difficult and of transitory benefit.
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