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Answer to your Health Question

Question (04/28/2012):

Title: Drug interaction between Benadryl (diphenhydramine) and Xanax (alprazolam).

For 8 years I have been taking 2 mg Xanax tid soma 350 mg tid and Percocet 10 mg Q 8hrs prn for neuromuscular disease and 50 mcg levothyroxine for hypothyroidism.

Can I take 25 mg Benadryl at night for allergies?

Brenda

Answer:

Dear Brenda,

There is a moderate probability of clinically significant drug interaction between Benadryl (diphenhydramine) and Xanax (alprazolam).

Usually avoid combinations; use it only under special circumstances.


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