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Question:

A checkup for my potential celiac disease has shown a positive HLA DQA1*0501 and Anti Gliadin IgA over 4.

What does it mean?

Randy

Answer:

Dear Randy,

Celiac disease (CD) susceptibility has been strongly associated with HLA-DQ2 and HLA-DQ8.

A study in the Department of Immunotechnology and Genomics, Center for Genetic Engineering and Biotechnology, Havana, Cuba, found in the group of celiac patients 86.3% were positive for DQA1*0501.

The study underlined the primary importance of HLA-DQ alleles in susceptibility to celiac disease.

The human leukocyte antigen system (HLA) is the name of the major histocompatibility complex (MHC) in humans. The super locus contains a large number of genes related to immune system function in humans.

In recent years, serum antibodies to gliadin (AGA) have been reported to be useful markers of celiac disease.

A research of V Hakeem, R Fifield, H F al-Bayaty, M J Aldred, D M Walker, J Williams, and H R Jenkins, has shown that high concentrations of Antigliadin IgA (average of 45 Optical Density Unit) were present in non treated celiac patients and treated patients showed an average of 4 Optical Density Unit.

Antibodies for gliadin (AGA), the toxic fraction of gluten are considered very sensitive but not specific for Celiac disease.

The few doctors who appreciate the spectrum of gluten intolerance or sensitivity are outnumbered by the medical majority that continue to insist on strict criteria for diagnosis for Celiac disease before recommending a gluten-free diet.

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