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Question:
My DHEA is 1490 (out of range high)
and my DHEA--sulfate is out of range low (I don't remember the exact number).
What does it mean?

Daniel


Answer: Dear Daniel,

The DHEA (Dehydroepiandrosterone) is an endogenous hormone (made in the human body), and secreted by the adrenal gland.

Dehydroepiandrosterone sulfate (DHEA-S) is the sulfated version of DHEA.

From a practical point of view, measurement of DHEAS is preferable to DHEA, as levels are more stable.

The normal range of DHEA-S is 40 ug/dl - 400 ug/dl
The normal range of DHEA is 42–290 µg/dL
ug/dL = microgram per deciliter

The secretion and the blood levels of the adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decrease profoundly with age.

DHEA levels in the body begin to decrease after age 30, and are reported to be low in some people with anorexia, end-stage kidney disease, type 2 diabetes (non-insulin dependent diabetes), AIDS, adrenal insufficiency, and in the critically ill. DHEA levels may also be depleted by a number of drugs, including insulin, corticosteroids, opiates, and danazol

Low levels of DHEA are present in female frigidity and male impotence.

The mechanism of action of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S),two interconvertable neurosteroids, has not been fully characterized in the central nervous system (CNS).

The concentration of DHEA-S in brain is some 7-12 times that of DHEA.

Low levels of DHEA sulfate are defined as less than 1000 nanograms per milliliter.

 

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