(Dehydroepiandrosterone) is an endogenous hormone (made in the human
body), and secreted by the adrenal gland.
sulfate (DHEA-S) is the sulfated version of DHEA.
From a practical point of view, measurement of DHEAS is preferable
to DHEA, as levels are more stable.
range of DHEA-S is 40 ug/dl - 400 ug/dl
The normal range of DHEA is 42290 µg/dL
ug/dL = microgram per deciliter
The secretion and the blood levels of the adrenal steroid dehydroepiandrosterone
(DHEA) and its sulfate ester (DHEAS) decrease profoundly with age.
levels in the body begin to decrease after age 30, and are reported
to be low in some people with anorexia, end-stage kidney disease,
type 2 diabetes (non-insulin dependent diabetes), AIDS, adrenal insufficiency,
and in the critically ill. DHEA levels may also be depleted by a number
of drugs, including insulin, corticosteroids, opiates, and danazol
Low levels of DHEA are present in female frigidity and male impotence.
The mechanism of action of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone
sulfate (DHEA-S),two interconvertable neurosteroids, has not been
fully characterized in the central nervous system (CNS).
The concentration of DHEA-S in brain is some 7-12 times that of DHEA.
of DHEA sulfate are defined as less than 1000 nanograms per milliliter.