What diseases or conditions a genetic variation can cause?
like to know what diseases or conditions can cause Benign Polymorphism
of the repeating TR sequence.
was the result of some DNA testing my neurologist had done.
from hypothyroidism, motor neuron disease, degenerative disc and joint
disease, multiple intestinal issues, and allergic alveolitis.
you very much for your question.
animals with genetic deficiencies in DNA repair often show decreased
life span and increased cancer incidence.
mice deficient in the dominant NHEJ pathway and in telomere maintenance
mechanisms get lymphoma and infections more often, and, as a consequence,
have shorter lifespans than wild-type mice.
manner, mice deficient in a key repair and transcription protein that
unwinds DNA helices have premature onset of aging-related diseases
and consequent shortening of lifespan.
not every DNA repair deficiency creates exactly the predicted effects;
mice deficient in the NER pathway exhibited shortened life span without
correspondingly higher rates of mutation.
rate of DNA damage exceeds the capacity of the cell to repair it,
the accumulation of errors can overwhelm the cell and result in early
senescence, apoptosis, or cancer.
of individual genes have been identified as influencing variations
in life span within a population of organisms.
of these genes is strongly dependent on the environment, in particular,
on the organism's diet.
restriction reproducibly results in extended lifespan in a variety
of organisms, likely via nutrient sensing pathways and decreased metabolic
rate. The molecular mechanisms by which such restriction results in
lengthened lifespan are as yet unclear; however, the behavior of many
genes known to be involved in DNA repair is altered under conditions
of caloric restriction.
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