How long should I take Isoniazid and Rifampin or Rifampicin .
you so much for your answer sir.
one more question.... Now my friend has been taken Antituberculosis
treatment for the past 15 months.
15 months first 3 months she took 4 drugs after that the doctor gave
only 2 drugs (isoniazid (INH) and rifampicin (RMP)).
patient takes these 2 drugs for 18 months (have to take 3 more months).
takes these 2 drugs together will these 2 drugs cause resistant TB?
have one more doubt all these drugs can cause liver problem?
taking liv52 tablet also... Please answer to my question
you very much for your question.
the bacteria may exist in a resting (nongrowing) state for long periods,
therapy with isoniazid (and other antituberculosis drugs) must be
continued for a long time (usually 6 to 12 months).
may cause severe and sometimes fatal liver damage.
has been shown to produce liver dysfunction.
regimen consisting of rifampin, isoniazid, and pyrazinamide (e.g.,
RIFATER®) is recommended in the initial phase of short-course
therapy which is usually continued for 2 months. The Advisory Council
for the Elimination of Tuberculosis, the American Thoracic Society,
and the Centers for Disease Control and Prevention recommend that
either streptomycin or ethambutol be added as a fourth drug in a regimen
containing isoniazid (INH), rifampin and pyrazinamide for initial
treatment of tuberculosis unless the likelihood of INH resistance
is very low.
the initial phase, treatment should be continued with rifampin and
isoniazid (e.g., RIFAMATE®) for at least 4 months. Treatment should
be continued for longer if the patient is still sputum or culture
positive, if resistant organisms are present, or if the patient is
drug-resistant tuberculosis (XDR-TB) is defined as TB that has developed
resistance to at least rifampicin and isoniazid (resistance to these
first line anti-TB drugs defines Multi-drug-resistant tuberculosis,
of the studies with Liv 52 and the results do not seem to be consistent.
Some studies show positive outcomes for Liv52 while others do not
show Liv52 to be beneficial in liver disease.
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