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Nodules on the left side of my tongue | Multiple endocrine neoplasia
have 2-3 nodules on the left side of my tongue after taking out 1.2cm
of nodules on the right, should I take them out?
out, are they likely to keep recurring?
assured me that if I don't have multiple endocrine neoplasia (MEN)
now, I would not get it in the future.
I do not have MEN now, what is the % risk of MEN in the future?
I send my son age 14 for a checkup also if I do not have MEN now?
a person gets MEN, what are the chances of survival if we go for regular
of the tongue can present a diagnostic and therapeutic dilemma for
growths usually require biopsy to differentiate benign lesions (e.g.,
granular cell tumors, fibromas, lymphoepithelial cysts) from premalignant
leukoplakia or squamous cell carcinoma.
condition is a Squamous cell carcinoma, with the following clinical
presentation: Thickened white or red patch or plaque, may develop
nodularity or ulceration, usually on lateral tongue,biopsy is critical
to confirm the diagnosis and allow for prompt treatment before extensive
local invasion occurs. Treatment typically requires surgery and
cell carcinoma doesn't have an extremely high recurrence rate,
meaning it isn't extremely likely that the cancer will come back after
multiple endocrine neoplasia (MEN) encompasses several distinct syndromes
featuring tumors of endocrine glands, each with its own characteristic
endocrine neoplasia (MEN) type I is disease passed down through families
in which one or more of the endocrine glands are overactive or form
with multiple endocrine neoplasia type 1 are born with one mutated
copy of the MEN1 gene in each cell. Then, during their lifetime,
the other copy of the gene is mutated in a small number of cells.
These genetic changes result in no functionalcopies of the MEN1 gene
in selected cells, allowing the cells to divide with little control
and form tumors.
with a combination of endocrine neoplasias suggestive of the MEN1
syndrome are recommended to have a mutational analysis of the MEN1
gene if additional diagnostic criteria are sufficiently met, mainly
-positive family history
-multifocal or recurrent neoplasia
-two or more organ systems affected
Medullary thyroid carcinoma is the primary concern for those
testing positive for the RET gene mutations. The survival rate
10 years after the initial diagnosis for Medullary thyroid carcinoma
is 46%. If the cancer is detected using genetic screening before the
patient shows signs of having the disease, surgical removal of the
thyroid gland can cure MTC.
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