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is composed of several types of cells, one of these are platelets,
cells that are useful for blood clotting.
are formed from cells called megakaryocytes, if they are affected
the number of platelets they produce is also affected.
is a decrease in platelet count.
clump together to plug the injured area and stop the bleeding when
a blood vessel is damaged and it begins to lose blood.
do not have the sufficient number of platelets, the cap is not performed,
and bleeding (or exit of blood) continues to have significant impact,
you can even bleed to death.
also carry serotonin and tryptophan, two substances involved in sleep-wake
cycles, appetite and mood.
in the number of platelets may be due to several reasons, either because
there is a low production, or an increase in its decomposition into
the bloodstream, spleen, or liver.
the causes of low production of these cells are diseases such as anemia,
bone marrow cancer, bone marrow infections and other illnesses.
case of viral hepatitis, thrombocytopenia may develop for various
is that the virus in the case of Hepatitis C directly affects the
megakaryocyte, the affected liver cells decreases the number of platelet
production and increases their destruction.
theory and the theory most studied in recent years is that some of
the drugs used to treat Hepatitis B and C, as pegylated interferon,
produce a decrease in platelet count.
antibodies that are produced in the immune system can accidentally
attack platelets (producing a condition called Immune thrombocytopenic
purpura or ITP).
have reported that acute immune thrombocytopenia often is associated
with Hepatitis A, B and C.
platelet count ranges between 150,000 and 400,000 platelets per cubic
millimeter of blood.
cases of thrombocytopenia, platelet counts may approach zero. In mild
cases, the platelet count is between 100,000 and 150,000.
platelet count falls below 30,000, it will present a high risk of
irreversible bleeding, and even cerebral hemorrhage.
depend on the severity of thrombocytopenia, a person with a mild one
thrombocytopenia may have no symptoms, in more severe cases frequent
and intense nosebleeds may be present, also known as epistaxis.
are medicines to treat thrombocytopenia mediating the immune system
in the case of immune thrombocytopenia, to bring down the destruction
of platelets; there are also drugs that help in the production of
with active bleeding and count of less than 30.000 platelets, guidelines
for action include:
1 dose of immunoglobulins intravenous (IGIV) and new assessment at
active bleeding persists it should be added corticosteroids and /
or a second dose of immunoglobulin intravenous (IGIV)
bleeding disappears a new assessment must done in the next 72 hours.
the problem is clinical and analytically overcome then pass observation,
but if persists by below of 20,000 or new active bleeding appears
then treatment with corticosteroids should be started.
immunoglobulin treatment may be tested in the case of Rh + or corticosteroid
bolus. In medicine, a bolus is the administration of a medication,
to raise its concentration in blood to an effective level.
who is refractory to previous treatment and persist with clinical
important bleeding must be sent to a specialized hospital for review
and assessment of third line treatments.
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