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Since May 2007 my dhea-sulfate is out of range. I am 44 years old .

I checked 4 times until now. I had 495,365, 285 and 225.

I feel bad. I am very tired and I have pain on my vagina and on my abdomen.

Please help me, the doctors said they don’t know what it is.

Thank you.



Dear Mariana,

DHEA sulfate goes to very high levels during reproductive years then falls off in the fourth, fifth, and sixth decades to very low levels.

DHEA sulfate is made in the amount of some 15 mg a day.
DHEA sulfate, a prohormone, may be of major importance in maintaining normal androgen output and production in women.

Elevated levels of DHEAS may indicate an adrenocortical tumor, adrenal cancer, or adrenal hyperplasia. Increased levels of DHEAS are not diagnostic of a specific condition; they usually indicate the need for further testing to pinpoint the cause of the hormone imbalance.

DHEA (Dehydroepiandrosterone) or pregnelone is an endogenous hormone (made in the human body) secreted by the adrenal gland.
After being secreted by the adrenal glands, it circulates in the bloodstream as DHEA-sulfate (DHEAS) and is converted as needed into other hormones.

DHEA serves as precursor to male and female sex hormones (androgens and estrogens).

Many patients with PCOD (Polycystic Ovary Disease) , a health condition associated with hormone imbalance, have a high dehydroepiandrosterone sulphate ( DHEA-S) level which can cause a cluster of symptoms in some women like pelvic pain , fatigue, depression, discomfort in the abdomen and vaginal pain.

Endometriosis is a notoriously difficult condition to diagnose. Fatigue, vaginal pain, abdominal pain and high DHEA levels are sometimes symptoms of endometriosis.High DHEA levels can often be associated with high stress although several variables can affect hormone levels such as medications, aging, environmental toxins, unhealthy lifestyle choices, excessive exercise, and improper diet.

At menopause, when ovarian function slows, there is sometimes a shift in the hormone pathway that favors the androgen hormones.

Medical conditions such as polycystic ovaries or androgen-secreting tumors will also elevate androgen levels.

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