HER+, breast cancer and Exemestane .
completed surgery for early-stage HER+ breast cancer.
are the benefits of switching to Exemestane after 2-3yrs?
refers to a gene that helps cells grow, divide, and repair themselves.
When cells have too many copies of this gene, cells -- including cancer
cells -- grow faster.
think that women with HER2-positive breast cancer have a more aggressive
disease and a higher risk of recurrence than those who do not have
is used to treat early breast cancer in women who have experienced
menopause and who have already been treated with a medication called
tamoxifen for 2 to 3 years.
is in a class of medications called aromatase inhibitors. It works
by decreasing the amount of estrogen produced by the body. This can
slow or stop the growth of some breast tumors that need estrogen to
side effects of Exemestane including grade 3 or 4 lymphocytopenia
(20% of patients in clinical trials for advanced breast cancer) and
infection have been reported.
side effects of Exemestane reported from animal studies have included
an increased incidence of hepatocellular adenomas and/or carcinomas
as well as an increased incidence of renal tubular adenomas.
has also been clastogenic in human lymphocytes in vitro without metabolic
may decrease bone mineral density and increase the chance of osteoporosis.
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