duo is a natural supplement. Its main ingredients are glucosamine
sulfate and chondroitin sulfate
sulfate can improve pain and movement in knees affected by osteoarthritis
based on information offered by RxList, The Internet Drug Index for
prescription drugs and medications.
use of non-prescription chondroitin sulfate products or compounds
appears to slow the worsening and ease the symptoms of osteoarthritis
of the knee,based on information offered by a European study, published
in the February 6, 2009 issue of Arthritis & Rheumatism.
found that people who used chondroitins 4 and 6 sulfate (CS) over
two years lost less joint spacethan those on a placebo.
of pain was most significant in the first year the participants
took the drug.
on information offered by Johns Hopkins Medicine large scale, independent
studies of glucosamine and/or chondroitin have not shown a definitive
benefit for the treatment of painful knee osteoarthritis (OA) and
the effect of retarding knee OA progression remains controversial.
considerations for Glucosamine Sulfate:
1500 mg once daily or 500 mg three times daily
is some concern that glucosamine products might cause allergic reactions
in people who are sensitive to shellfish.
sulfate seems to be safe for most people. It can cause some mild side
effects including nausea, heartburn, diarrhea, and constipation.
side effects are drowsiness, skin reactions, and headache.
considerations for Chondroitin Sulfate:
of 200-400 milligrams by mouth twice to three times daily, or 800-1,200
milligrams once daily have been used in studies. Higher doses (up
to 2,000 milligrams) appear to have similar efficacy. In the treatment
of osteoarthritis, full effects may take several weeks to occur.
not clear what dose is optimal when used in combination with glucosamine
or whether the combination is as effective as or more effective than
either agent alone.
50-100 milligrams as a single daily injection or divided into two
daily injections has been used. Medical supervision is recommended.
sulfate seems to be safe for most people. It can cause some mild stomach
pain and nausea. Other side effects that have been reported are diarrhea,
constipation, swollen eyelids, legswelling, hair loss, and irregular
chondroitin products contain excess amounts of manganese.