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Answer to your Health Question

Question (08/12/2012):

Title: Interactions among Picot Antacid, Cozaar and Pravastatin Sodium.

Can you mix these meds?

Picot antacid and cozaar 100mg and pravastatin sodium 40 mg

Goldie

Answer:

Dear Goldie,

Ingredients of picot antacid are: SODIUM BICARBONATE 2.485g, and CITRIC ACID 1.948g

Inactive ingredients are sucrose, tartaric acid, silicon dioxide

Antacids can interfere with the absorption of:

-Phosphate supplements (e.g., potassium phosphate)
-Sodium polystyrene sulfonate
-Drugs that can be affected by the amount of acid in your urine (e.g., amphetamines, quinidine, salicylates such as aspirin)

Cozaar is in a group of drugs called angiotensin II receptor antagonists.

Pravastatin is in a class of medications called HMG-CoA reductase inhibitors (statins).

Losartan (Cozaar), which is a typical agent among angiotensin-II-receptor blockers, and Pravastatin, which is a typical agent among HMG-CoA reductase inhibitors, are the most frequently used in combination therapies.

Although HMG-CoA reductase inhibitors such as statins are the most widely used cholesterol-lowering agents, there is a risk of myopathy or rhabdmyolysis occurring in patients taking these drugs.

The strategy to combine statins with bicarbonate can lead to reduction in the chance of the severe adverse events including myopathy or rhabdmyolysis.

According F Y Liu and M G Cogan (The Journal of Clinical Investigation 1989 July) angiotensin II increases bicarbonate absorption.


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