Treatment of very low levels of Vitamin D-25 hydroxy caused by hypothyroidism.
have hypothyroidism sarcoidosis and peripheral neuropathy.
hydroxy levels were 12.5 so my endocrinologists put me on 50,000 units
my levels 6 months later and the level was 13.
changed the dose to 50,000 twice weekly.
6 months he rechecked the levels and they were 5.9 ng/ml.
on why they keep dropping or what to do about it?
kind of disease would cause this?
is more than just deficiency
you very much for your question.
thought that one of two mechanisms may explain the low levels of vitamin
D in patients with hypothyroidism, 1) the low levels of vitamin D
may be due to poor absorption of vitamin D from the intestine or 2)
the body may not activate vitamin D properly.
D itself is inactive and needs to get converted to the liver to 25-hydroxy
vitamin D (25-OH vitamin D) and then in the kidney to 1, 25-hydroxy
only the 1, 25- OH vitamin D which is biologically active.
that are vitamin D deficient usually have a low 25-OH vitamin D level
of a 2011 study of Tamer G, Arik S, Tamer I and Coksert D., was that
Vitamin D insufficiency (defined as serum levels of 25-hydroxyvitamin
D [25(OH)D3] lower than 30 ng/mL)is associated with HT or Hashimoto's
studies are needed to determine whether vitamin D insufficiency is
a casual factor in the pathogenesis of Hashimoto's thyroiditis or
rather a consequence of the disease.
thyroiditis is the most common cause of hypothyroidism.
D deficiency is common in sarcoidosis patients.
of a 2011 study of D. Shehab, K. Al-Jarallah, O. A. Mojiminiyi, H.
Al Mohamedy and N. A. Abdella, was that Vitamin D deficiency is an
independent risk factor for diabetic peripheral neuropathy, and further
studies are required to confirm if Vitamin D supplementation could
prevent or delay the onset.
study regarding the substitution therapy with thyroid hormone may
J, Lakatos P, Foldes J, Feher T - "Effect of vitamin
D3 loading and thyroid hormone replacement therapy on the decreased
serum 25-hydroxyvitamin D level in patients with hypothyroidism"
Acta Endocrinol (Copenh) 113(3):329-34 (1986)
hypothyroid subjects, 13 healthy and 12 healthy women with a slight
deficiency of vitamin D were studied to distinguish seasonal changes
from the thyroxine-dependent ones.
25-hydroxyvitamin D levels of hypothyroid patients were lower than
those of healthy individuals when the sera were obtained in the autumn.
patients a single oral dose of 100,000 IU vitamin D3 resulted in a
smaller increase in 25-hydroxyvitamin D concentration than in controls
having subclinical exogenous vitamin D deficiency.
therapy with thyroid hormone, started in our study always in autumn,
increased the 25-hydroxyvitamin D concentration in hypothyroid patients,
which was opposite to the autumn-to-spring variation of this hormone
observed in healthy controls.
of 25-hydroxyvitamin D, dehydroepiandrosterone and its sulphate values
following substitution therapy in the hypothyroid patients may indicate
that thyroid hormone(s) is (are) involved in the regulation of steroid
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