Question (08/24/2011):

Title: Grape seed interaction with Antibiotics for tuberculosis and Chemotheraphy | Doses .

When is grapeseed best taken?

It is before meal or after meal?

Can it be taken with antibiotics for tuberculosis?

Can it be taken by person undergoing chemotheraphy?

If so, what dose should be given?

Thank you

Maribel

Answer:

Dear Maribel,

Grapeseed should be taken with breakfast and lunch for two weeks and then with breakfast daily.

Isoniazid is used in the treatment of tuberculosis and because of its effectiveness and low cost is considered as a drug of first choice. Isoniazid is more effective and less toxic than other anti-tuberculosis drugs including p-aminosalicylic acid, capreomycin, cycloserine, ethionamide and kanamycin.

Although isoniazid does not seem to inhibit monoamine oxidase mitochondrial it does seem to have a MAOI activity high enough to produce significant clinical effects when taken with tyramine-rich foods or drugs that inhibit the activity of monoamine oxidase.

These clinical effects are manifested as flushing, palpitations and headaches. The following foods should be limited during treatment with isoniazid due to its high content of tyramine: aged cheeses, bananas, avocados, beans, smoked fish, herring, soy sauce and yeast extracts and meat.

Moreover, caffeine and drinks containing this substance such as tea, colas, chocolate or coffee can cause serious cardiac arrhythmias or hypertensive crisis if consumed while treatment is administered with an MAOI

Grape seed extract may break down Tyramine.

One of the ways that radiation and chemotherapy damage the cells is by forming free radicals.

Grape seed extract is one of the most powerful antioxidants that fight free radicals.

Studies that have used the grape seed extract have been done with doses ranging from 40 mg to 720 mg daily.

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